Prospective and physicochemical analysis of bioactive compounds from the species Camptotheca acuminata against cancer in silico
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https://doi.org/10.17564/2316-3151.2025v9n2p99-118Keywords:
cancer, Natural extracts, Camptotheca acuminata
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Copyright (c) 2025 Caderno de Graduação - Ciências Biológicas e da Saúde - UNIT - SERGIPE
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Abstract
Introduction: Cancer is a group of more than 100 diseases characterized by disordered cell proliferation, which can lead to invasive tumors and spread to other organs. Despite advances in conventional treatments, such as chemotherapy and radiotherapy, there are still important limitations, such as resistance and side effects. This drives the search for therapeutic alternatives, such as bioactive compounds from medicinal plants. Objective: To prospectively and physicochemically analyze the bioactive compounds of the species Camptotheca acuminata against cancer, through in silico studies. Methodology: Scientific prospecting was carried out in databases such as SciELO, PubMed and ScienceDirect, using descriptors in Portuguese and English combined with the Boolean operator AND. Technological prospecting used the WIPO and INPI patent databases. The physicochemical analysis of the compounds was performed using PubChem, SwissADME and PreADMET. Results: The physicochemical analysis revealed good gastrointestinal absorption and therapeutic potential, although there are limitations related to toxicity, low solubility and permeability. Strategies such as the use of nanoparticles can improve their clinical efficacy in the treatment of cancer. Camptothecin and topotecan stood out for acting on crucial pathways, such as apoptosis. 1,636 patents were found in WIPO and none in INPI. Conclusion: Although there is ample scientific production on cancer and natural extracts, there is little national technological innovation. Camptotheca acuminata shows promising potential, justifying the need for further studies and investments in innovation.
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